Stellate Ganglion Block for Long Covid: Exploring a Potential Path to Relief
- Aubrey Verdun
- Apr 14
- 6 min read
Updated: Apr 15

The aftermath of a COVID-19 infection has led to a range of persistent symptoms collectively known as “long COVID.” Among these symptoms, dysautonomia, chronic pain, and lingering neurological issues have posed significant challenges for patients worldwide. One emerging therapeutic approach is the stellate ganglion block—a procedure that has shown promise in addressing some of the debilitating symptoms associated with long COVID. In this post, we delve into how a stellate ganglion block may offer relief, explore its mechanism of action, review current research, and discuss important safety considerations to empower patients and healthcare providers in their journey toward recovery.
Understanding Long COVID
Long COVID, sometimes referred to as post-acute sequelae of SARS-CoV-2 infection (PASC), affects a broad spectrum of individuals who continue to experience COVID symptoms long after the initial infection has cleared. These symptoms can include:
Neurological Complaints: This might include brain fog, headaches, and/or radiation of pain.
Dysautonomia: Characterized by an imbalance in the autonomic nervous system, this symptom can lead to irregular heart rhythms, blood pressure fluctuations, and temperature regulation issues.
Chronic Pain and Fatigue: Persistent pain or exhaustion that can severely limit one’s daily activities and overall quality of life.
This ongoing condition can be both physically and emotionally taxing, underscoring the pressing need for innovative treatment options.
What Is a Stellate Ganglion Block?
A stellate ganglion block (SGB) is a minimally invasive procedure that involves the injection of a local anesthetic near the stellate ganglion, a collection of sympathetic nerves located in the neck. Traditionally used to treat conditions such as complex regional pain syndrome (CRPS) and migraines, this nerve block aims to temporarily interrupt the sympathetic nerve signals that contribute to pain and autonomic dysfunction.
When considering the stellate ganglion block long COVID treatment, it is important to note that many healthcare professionals and researchers are currently exploring whether disrupting the overactive sympathetic nervous system could also alleviate some of the symptoms observed in long COVID patients—especially those related to dysautonomia and chronic pain.
How Might Stellate Ganglion Block Help with Long COVID?
The logic behind using a stellate ganglion block for long COVID centers on its ability to modulate the sympathetic nervous system. Here’s how it may be beneficial:
Addressing Autonomic Imbalance
Long COVID patients often experience dysregulation in autonomic functions. By mitigating excessive sympathetic activity, the SGB may help rebalance the nervous system. This could potentially result in:
Stabilized heart rate and blood pressure, leading to improved cardiovascular comfort.
Reduced inflammation, as nerve-mediated inflammatory responses may be subdued.
Alleviated pain levels by decreasing the nerve signals that contribute to chronic pain.
Neurological Benefits
Some patients with long COVID report persistent neurological symptoms, such as headaches and brain fog. Through its impact on the stellate ganglion, the SGB may also have a role in calming these disturbances, potentially improving overall neurological function.
A Multimodal Approach
It is important to view the stellate ganglion block not as a standalone cure, but as a complementary intervention. Many patients with long COVID benefit most when such procedures are incorporated into a broader multidisciplinary treatment plan that includes:
Physical Rehabilitation
Long COVID often leaves patients with significant deconditioning, persistent fatigue, and reduced exercise tolerance. Specialized physical therapy programs can help rebuild strength and endurance through carefully paced activities. Physical rehabilitation for long COVID typically includes graded exercise therapy, respiratory exercises to improve lung function, and techniques to manage post-exertional malaise. This component works synergistically with stellate ganglion blocks by helping the body rebuild physical capacity while the block addresses underlying autonomic dysfunction.
Psychological Support
The chronic nature of long COVID symptoms can lead to significant psychological distress, including anxiety, depression, and trauma responses. Professional mental health support provides coping strategies for living with persistent symptoms and tools for managing the uncertainty that accompanies long COVID. Therapeutic approaches such as cognitive behavioral therapy (CBT), acceptance and commitment therapy (ACT), and trauma-focused interventions can complement the physiological benefits of stellate ganglion blocks by addressing the mind-body connection in recovery.
Nutritional and Lifestyle Modifications
Many long COVID patients experience gastrointestinal symptoms, changes in appetite, and disrupted sleep patterns. Nutritional guidance focusing on anti-inflammatory foods, adequate hydration, and appropriate supplementation can support immune function and energy levels. Lifestyle modifications including sleep hygiene practices, stress management techniques, and pacing strategies help manage limited energy reserves. These modifications create an optimal foundation for recovery that enhances the effectiveness of medical interventions like stellate ganglion blocks.
When combined thoughtfully, these complementary approaches address the complex, multisystem nature of long COVID, potentially creating synergistic effects that improve outcomes beyond what any single intervention might achieve alone.
Examining the Emerging Research
While the current research on the stellate ganglion block for long COVID treatment is still in its early stages, case studies and small clinical trials point toward several potential benefits. Through further trials, researchers are trying to understand:
The Duration of Symptom Relief: Determining how long the effects of the block last and whether repeated treatments are necessary.
Optimal Protocols: Finding the most effective dosage, frequency, and technique to maximize benefits while ensuring safety.
Patient Selection: Identifying which patients are most likely to benefit based on their long COVID symptom profile, particularly those exhibiting clear signs of autonomic dysregulation.
Although preliminary findings are promising, more extensive and controlled studies are needed to establish the efficacy and safety of this procedure specifically for long COVID patients.
The Stellate Ganglion Block Procedure Explained
For patients considering the SGB treatment, understanding the steps of the procedure can help reduce anxiety and set realistic expectations. The process involves:
Pre-Procedure Evaluation: Before the procedure, patients will undergo a thorough assessment to evaluate their overall health and ensure they are a good candidate for the block. This may include a review of the patient’s medical history, a physical examination, and discussions about previous treatments and current symptoms.
Preparation: First, the patient is positioned comfortably, and the targeted area in the neck is cleaned and prepped. Ultrasound guidance is often used to precisely locate the stellate ganglion.
Injection: A local anesthetic is carefully injected near the stellate ganglion. The goal is to block the nerve signals for a period that can vary from several hours to several days.
Monitoring: After the injection, patients are observed for any immediate effects or adverse reactions. Most patients, however, experience a decrease in sympathetic activity without significant complications.
Follow-Up: Further assessments will help determine the level of symptom relief and whether additional sessions might be beneficial for the patient.
It is crucial that this procedure is performed by an experienced healthcare professional—typically one specializing in pain management and/or interventional radiology—to better minimize risks and optimize outcomes.
Safety Considerations and Potential Side Effects
Like any medical procedure, the stellate ganglion block comes with some potential risks and side effects. These may include:
Temporary Hoarseness or Difficulty Swallowing: This can occur due to the proximity of the injection site to nerves that control vocal cords and swallowing.
Injection Site Pain: Mild pain or swelling at the injection site may occur, but this typically resolves quickly.
Rare Complications: Though it is uncommon, infections or nerve injuries can occur as a result of this procedure, which underscores the importance of receiving treatment from qualified health professionals.
Patients should be thoroughly evaluated beforehand to determine if they are good candidates for the procedure, and discussions about the potential benefits and risks should occur prior to treatment.
Looking Ahead: Integrative Care for Long COVID
The potential of the stellate ganglion block as a treatment for long COVID symptoms opens doors to further integrative care approaches. Combining this procedure with other effective treatments might provide a holistic management strategy that caters to the complex needs of long COVID patients. Healthcare providers are encouraged to:
Stay Updated on Emerging Research: As more studies are published, guidelines and best practices will continue to evolve.
Individualize Patient Treatment Plans: Not every patient with long COVID will require or benefit from an SGB, so personalization is key.
Engage in Multidisciplinary Collaboration: Coordination among primary care physicians, pain specialists, neurologists, and rehabilitation experts ensures that the patient receives optimal comprehensive care.
Conclusion: Empowering Recovery Through Informed Choices
The exploration of the stellate ganglion block for long COVID treatment represents an innovative step toward addressing some of the lingering effects of COVID-19. While this treatment is still under investigation, its potential to modulate the autonomic nervous system and reduce chronic pain offers a beacon of hope for many struggling with long COVID symptoms.
For those considering this option, it is vital to start by having an open dialogue with your healthcare provider. By discussing your symptoms, treatment expectations, and medical history, you can make an informed decision about whether a stellate ganglion block might be a beneficial component of your long COVID recovery plan.
If you or a loved one has been grappling with long COVID and its challenging symptoms, including autonomic dysregulation and chronic pain, talk to your healthcare provider about the potential benefits of a stellate ganglion block. With the right information and support, you can empower yourself to explore innovative solutions on your path to recovery.
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